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Prof. Sandhaus

Professor Sami Sandhaus

Associated Professor of the Stomatology Institute,

Pierre and Marie Curie University, Paris Ⅵ

Member of the French Academy for Dental Surgery

Member of the Center for Restorative Dentistry (USA)

Member of honour of the Academy of Romanian Scientists

Forum Odontologicum

Avenue de Provence 4

Course Ⅳ - Immunocompatibility

Objective: restore biocompatibility

Ignoring the laws governing immunology had as a consequence the common use of certain metals in dental medicine. These materials frequently induced an important metabolic unbalance, leading sometimes to serious or even irreversible pathologies, as metabolism varies from patient to patient.

After the eviction of an amalgam, even by using the best techniques and precautions ever, metallic ions will persist in the dentinal micro-tubules, contaminating this underlying tissue. This is far from being negligible, as the recorded amounts of the mercury concentration in the oral cavity showed almost identical values before and after the amalgam removal.

Very early aware of this problem, in 2001, at the Munich University, Professors Sandhaus, Rasch and Dr. Roider succeeded to develop, after several years of research, a formula and a local chelation protocol at the interior of the coronary cavity.

Research carried out show that gold and amalgams are not harmless, that “… lead from amalgams can weaken the immune system”. The gold-based amalgams have to be regarded in a critical way, as the resorbed gold may have immunosuppressive effects. Clinical aspects prove our assertions.


  1. Physiopathology
    1. 1) Metallic ions and their migration
      • Biocompatibility profile
      • Instability of amalgams
      • Bimetallism
      • Contiguity migration
      • Systemic migration
      • Immunotoxic pathology
      • Metalloid pathology
      • Distinctive test for the use of materials
      • The role of immunology. Differential diagnosis
      • Cytotoxicological research
      • Clinical survey
    2. Poisoning
      • Definition
      • Predisposing factors
      • Reported pathologies
  2. Medical care
    1. Different tests
      • Poisoning
      • Hypersensitivity
    2. Local techniques of cavity chelation
      • Detoxification
      • Desensitization
      • Nutritional supplement
  3. Safe eviction of dental metallic restorations
    • Aspiration in closed circuit
    • Removal by breaking-up
    • Chelation of the coronary cavity after the amalgam eviction
    • Chelating bandage for the cavity detoxification and its importance
    • Cavity decontamination
  4. Permanent substitution material: zircon
    • In conservative dentistry: use of zirconite (replacing all obturation)
    • Use of the zircon post for the radicular reconstruction (by zircon biopost)
    • Use of zircon in restorative dentistry.

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Immunological problems of the oral cavity

The use of certain materials in dental medicine gave way to the misreading of the laws governing the immune aspect, especially the use of certain metals. Indeed, each patient has an individual and changing chemistry. Chemical components used in the current practice can lead to serious or even irreversible pathological disasters. Some metals presented not only maladaptation, but also a serious metabolic unbalance.

Research conducted by Sandhaus, Rasch and Roider at the Munich University show therefore that, in certain cases, metals known as noble, such as gold, can be dangerous. Mercury from amalgams can weaken the immune system and have immunosuppressive effects. Clinical tests corroborate these results.

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